Scientific Board

Prof. Doutor Rui António Tato Marinho

Prof. Doutor Rui António Tato Marinho

Areas of Interest

• Hepatitis C: immunology, epidemiology, therapy, social issues, drug addiction, homeless and PWID.
• Hepatitis B: therapy.
• Hepatocellular carcinoma: epidemiology, therapy
• Palliative Care in Liver Diseases
• Alcohol, (traffic accidents, liver disease, social issues, young people).
• Medical Publishing and editing, five years as an editor-in-chief of a Web of Science/Pubmed indexed medical journal.
• Health Management
• Medical teaching, medical pedagogy

Academic degrees

  • Medical School: Faculdade Ciências Médicas, Universidade Nova Lisboa, 1982. Graduation 17/20. Auxiliary Professor at 30%.
  • Aggregation with unanimity in Medical School of Lisbon in 2015.
  • PhD Thesis: T-cell immunity in pathogenesis of hepatitis C chronic infection. Contribution for a vaccine development. Medical School of Lisbon, Hospital S. Maria, Universidade Lisboa. Graduation with unanimity 20/20, 2002.
  • Specialist in Gastroenterology, Subspecialist in Hepatology by the Portuguese Medical Association of Portugal, number 26118
  • 1986-1991: Completed specialization in Gastroenterology, Hospital S. Maria.
  • 1992-1994: Course of special studies in Hepatology, Liver Unit, Hospital S. Maria.
  • 2005: Recognized as subspecialist in Hepatology by the Portuguese Medical Association

Pedagogical experience

  • Teaching activity: since 1987, in Medical School of Lisbon, 1st, 3th, 5th and 6th year.
  • Full Associate Professor since 2016.

Professional activity

  • Head of Department of Gastroenterology and Hepatology, University Hospital of Santa Maria, Lisbon, Portugal, recognised Centre for Training in Gastroenterology and Hepatology by the European Board of Gastroenterology and Hepatology (2009).
  • Fellow of American Association for the Study of the Liver Diseases
  • Advisor to ELPA (European Liver Patient Association) Governing Board
  • Expert for the European Commission Programme Horizon 2020, 2016-2017
  • United European Gastroenterology-UEG (Elected Member of General Assembly, Selected for “Visiting Fellowships for Clinicians”, Mentoring Programme, UEG Week 2017
  • President of Digestive Week 2017
  • Medal of Merit of Portuguese Medical Association, 2015
  • Adviser of Viral Hepatitis Prevention Board, www.vhpb.org, since 2008.
  • Fellow of European Board of Gastroenterology and Hepatology (FEBGH), since 2009.
  • Member of Pedagogic Committee of Medical School of Lisbon, since 2011.
  • Member of Scientific Board of Masters in Palliative Care, Medical School of Lisbon.
  • Organizer of 24 meetings including the Digestive Week (National Congress of Gastroenterology) 2017 and International Network Hepatitis in Substance Users, Portugal, 2018
  • Central Administration of the Health System (ACSS), Ministry of Health. Member of the group for the preparation of documents on the specialty of gastroenterology and hepatology for the National Network of Hospital Specialty and Referencing. The final document was delivered in July 2016. It has been coordinated by Profª. Isabel Pedroto. I was responsible for the preparation of the text about liver disease, epidemiological impact and training, together with Prof. Guilherme Macedo, 2016-2017.
  • Member of the Commission for Clinic Years Reform, Medical School of Lisbon, 2015-2018.
  • Member of Scientific Commission of Masters in Palliative Care of Medical School of Lisbon, 2014-2018.
  • Member of Pedagogic Committee of Medical School of Lisbon, 2014-2017 and 2017-2020.
  • Coordenator of the advisory group of INFARMED for HCV therapy (2014-2015).
  • Vice-President (2013-2019), General-Secretary (2005-2007) of Portuguese Society of Gastroenterology.
  • Editor of PSG News webletter (2013-2017), having now being published around 210 issues.
  • President of Portuguese Board of Hepatology (2013-2015)
  • Member of the Scientific Course in Medical Law and Criminal Justice (2015-2018) and the Centre for Research Institute of Criminal Law and Criminal Sciences (since 2014). Faculty of Law, University of Lisbon.
  • Member of Scientific Committee for the National Strategy for the Approach of Viral Hepatitis (Ministry of Health, Direção-Geral da Saúde), since May 2014. Coordinator of the guidelines for the new DAAs - 2015.
  • President of College of Hepatology for the Portuguese Medical Association, 2012-2015.
  • Editor-in-Chief of Acta Médica Portuguesa, Scientific Journal of Portuguese Medical Association (2011-2016), IF, Thomson-Reuters.
  • Editor-in-chief of the Portuguese Journal of Gastroenterology, 2009 – 2011. Member of Editorial Board 1997 – 2005.Now indexed in PubMed, since 2017.
  • Portuguese Society of Gastroenterology: General-Secretary: 2005–2007. Member of the Board since 2001.
  • Portuguese Association for Study of Liver: President 2007–2009, General-Secretary 1993-1997.
  • Webmaster of the site of the Portuguese Society of Gastroenterology (www.spg.pt), 2000–2007.
  • President of the Editorial Commission of Portuguese Society of Gastroenterology, 2013-2015.
  • President (2007-2009) and General-Secretary (1993-1997) of Portuguese Association for the Study of The Liver
  • President of the National Centre of Data Registry in Gastroenterology, 2006 – 2010.
  • Vogal of Fiscal Commission for Molecular Institute of Medicine, 2008-2017.
  • Member of the Ethics Commission of “Instituto Droga e Toxicodependência”, 2006.

 Clinical Activity

  • Outpatient Clinic (1906 consultations in year 2016: general hepatology, therapy of viral hepatitis), Inpatient Clinic (Liver Unit), Emergency (Intensive Care Unit of Gastroenterology and Hepatology, Department of Gastroenterology). Regular performance of liver biopsy, Fibroscan®.
  • Coordinator of the outpatient Department of Gastroenterology of Hospital Santa Maria (35 doctors, 24.000 Consultations/year) since October 2008.Publications

Publications

93 papers in PubMed inc. NEJM, Gastroenterology, Liver International, Journal Viral Hepatitis, Annals Oncology, Lancet Gastr Hepatol, World J Gastroenterol, Endoscopy, etc

Articles in scientific magazines and book chapters (last publications)

  • Palladino C, Ezeonwumelu I, Marcelino R, Briz V, Moranguinho, Serejo F, Velosa J, Marinho RT, Borrego P, Taveira N. Epidemic history of hepatitis C virus genotypes and subtypes in Portugal. Scientific Reports 2018.
  • Hepatitis C Virus infection: "beyond the liver" Arrais de Castro, Rui; Vilas, Paula; Borges-Costa, João; Tato Marinho, Rui. BMJ Case Reports 2018.
  • Fernandes S, Marinho R. The dark side of the long-term use of proton pump inhibitors in chronic liver disease. GE J Port Gastroenterol 2018. DOI: 10.1159/000489640.
  • Carvalho JR, Vasconcelos M, da Costa PM, Marinho RT, Fatela N, Raimundo M, Carvalhana S, Ramalho F, Cortez-Pinto H, Velosa J. Identifying palliative care needs in a portuguese liver unit. Liver Int. 2018 Apr 23. doi: 10.1111/liv.13865.
  • Puoti M, Foster GR, Wang S, Mutimer D, Gane E, Moreno C, Chang TT, Lee SS, Marinho R, DuFour JF, Pol S, Hezode C, Gordon SC, Strasser SI, Thuluvath PJ, Zhang Z, Lovell S, Pilot-Matias T, Mensa FJ. High SVR12 with 8-week and 12-week Glecaprevir/Pibrentasvir: Integrated Analysis of HCV Genotype 1-6 Patients Without Cirrhosis. J Hepatol. 2018 Mar 15. pii: S0168-8278(18)30165-X. doi:10.1016/j.jhep.2018.03.007.
  • Rocha MC, Marinho RT, Rodrigues T: The mortality associated with hepatobiliary disease in Portugal between 2006 and 2012. GE Port J Gastroenterol DOI: 10.1159/ 000484868.
  • Marshall A, Cunningham E, Nielsen S, Aghemo A, Alho H, Backmund M, Bruggmann P, Dalgard O, Seguin-Devaux C, Flisiak R, Foster G, Gheorghe L, Goldberg D, Goulis I, Matthew Hickman, Hoffmann P, Jancorienė L, Jarcuska P, Martin Kåberg, Leondios G Kostrikis, Mihály Makara, Matti Maimets, Rui Tato Marinho, Mojca Matičič, Suzanne Norris, Sigurður Ólafsson, Anne Øvrehus, Jean-Michel Pawlotsky, Pocock J, Geert Robaeys, Carlos Roncero, Marieta Simonova, Jan Sperl, Michele Tait, Ieva Tolmane, Stefan Tomaselli, Marc van der Valk, Vince A, Gregory J Dore, Jeffrey V Lazarus*, Jason Grebely*, on behalf of the International Network on Hepatitis in Substance Users (INHSU). Restrictions for reimbursement of interferon-free direct-acting antiviral drugs for HCV infection in Europe). Lancet Gastroenterol Hepatol 2017.
  • Kuppili V, Biswas M, Sreekumar A, Suri HS, Saba L, Edla DR, Marinhoe RT, Sanches JM, Suri JS. Extreme Learning Machine Framework for Risk Stratification of Fatty Liver Disease Using Ultrasound Tissue Characterization. J Med Syst 2017;41:152. IF 2,456.
  • Asselah T, Kowdley KV, Zadeikis N, Wang S, Hassanein T, Horsmans Y, Colombo M, Calinas F, Aguilar H, de Ledinghen V, Mantry PS, Hezode C, Marinho RT, Agarwal K, Nevens F, Elkhashab M, Kort J, Liu R, Ng TI, Krishnan P, Lin CW, Mensa FJ. Efficacy of Glecaprevir/Pibrentasvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2, 4, 5, or 6 Infection Without Cirrhosis. Clin Gastroenterol Hepatol. 2018;16:417-426. doi: 10.1016/j.cgh.2017.09.027.  IF 7,398.
  • Libânio D, Marinho RT. Impact of hepatitis C oral therapy in portal hypertension. World J Gastroenterol 2017; 23: 4669-4674.
  • Homie Razavi, Sarah Robbins, Stefan Zeuzem, Francesco Negro, Maria Buti, Ann-Sofi Duberg, Françoise Roudot-Thoraval, Antonio Craxi, Michael Manns, Rui T Marinho, Bela Hunyady, et al. Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study. The Polaris Observatory HCV Collaborators. Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study. Lancet Gastroenterol Hepatol 2017;2:161-176.
  • European Union HCV Collaborators. Hepatitis C virus prevalence and level of intervention required to achieve the WHO targets for elimination in the European Union by 2030: a modelling study. Lancet Gastroenterol Hepatol 2017;2:325-336.
  • Medical Education in Portugal. Ribeiro JC, Donato H, Massano J, Marinho RT. Acta Med Port 2016.
  • Me, the Editor-In-Chief and the Puzzle Work. Marinho RT. Acta Med Port 2016.
  • Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study. The Polaris Observatory HCV Collaborators. Lancet Gastroenterol Hepatol 2016 Published Online December 15, 2016 http://dx.doi.org/10.1016/ S2468-1253(16)30181-9.
  • Marinho RT, Costa A, Pires T, Raposo H, Vasconcelos C, Polónia C,Borges J, Soares M, Vilar G, Nogueira AM. A multidimensional education program at Substance Dependence Treatment Centers improves patient knowledge and hepatitis C care BMC Infectious Diseases 2016.
  • Fernandes SR, Santos P, Fatela N, Baldaia C, Tato Marinho R, Proença H, Ramalho F, Velosa J. Ascitic Calprotectin Is a Novel and Accurate Marker for Spontaneous Bacterial Peritonitis. J Clin Lab Anal 2016;30:1139-1145.
  • Vitor S. Marinho RT, Giria J, Velosa J. An observational study of the direct costs related to hospital admissions, mortality and premature death associated with liver disease in Portugal. BMC Res Notes 2016;9:62.
  • Meireles LC, Marinho RT, Van Damme P. Three decades of hepatitis B control with vaccination. World J Hepatol 2015;7:2127-2132.
  • Donato H. Marinho RT. Dicas para Escrever um Título. Tips for a Title. Acta Med Port 2015;28:269-270.
  • Pestana PC, Marinho RT. Dez Conquistas nos 35 anos do Serviço Nacional de Saúde Português (1979 - 2015): Pensar Passado e Projetar Futuro. Ten Achievements for 35 years of the Portuguese National Health Service (1979-2015): Looking Back, Planning the Future. Acta Med Port 2015.;28):135-137.
  • Pierre Van Damme, Tinne Lernout, Koen Van Herck, Rui T Marinho, Raymundo Parana, and Daniel Shouval. .Chronic hepatitis and other liver disease. Chapter 8, section 8.16, p. 1175-1191; in Oxord Textbook of Global Public Health, 6th Edition, Eds: Roger Detels, Martin Gulliford, Quarraisha Abdool Karim, Chorh Chuan Tan, Oxford University Press, 2015.
  • Marinho RT, Donato H. [Welcome aboard the acta medica portuguesa, welcome to the first international division!]. Acta Med Port 2014;27:533-4.
  • Ferreira A, Marinho RT. Risky business — the real life of the unresolved HCV therapy. Gastroenterology 2014; Gastroenterology 2014;147:1185–1187.
  • Marinho R. 'The last coachman', the trio of risk factors: alcohol, tobacco and traffic accidents. Acta Med Port 2014;27:406-7.
  • Ferenci P, Bernstein D, Lalezari J, Cohen D, Luo Y, Cooper C, Tam E, Marinho RT, et al. ABT-450/r-Ombitasvir and Dasabuvir with or without Ribavirin for HCV. N Engl J Med. 2014 May 4. [Epub ahead of print] PubMed PMID: 24795200.
  • Zeuzem S, Jacobson I, Baykal T, Marinho RT, Poordad F, Bourlière M, et al. Retreatment of HCV with ABT-450/r–Ombitasvir and Dasabuvir with Ribavirin. N Engl J Med 2014;370:1604-14. DOI: 10.1056/NEJMoa1401561.
  • Bruggmann P, Berg T, Ovrehus AL, Moreno C, Brandão Mello CE, Roudot-Thoraval, F, Marinho RT, et al. Historical epidemiology of hepatitis C virus, (HCV) in selected countries. J Viral Hepat 2014;21 Suppl 1:5-33.
  • Razavi H, Waked I, Sarrazin C, Myers RP, Idilman R, Calinas F, (…) Marinho RT, (…) et al.  Present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm. J Viral Hepat 2014;21 Suppl 1:34-59.
  • Wedemeyer H, Duberg AS, Buti M, Rosenberg WM, Frankova S, Esmat G, (…) Marinho RT,(…), et al. Strategies to manage hepatitis C virus (HCV) disease burden. J Viral Hepat 2014;21 Suppl 1:60-89.
  • Marinho RT, Duarte H, Nunes J, Ferreira A, Giria J, Velosa J. The burden of alcoholism in fiteen years of liver cirrhosis hospital admissions in Portugal. Liver Int. 2014 Apr 22. doi: 10.1111/liv.12569. [Epub ahead of print] PubMed PMID: 24750642.
  • Marinho RT, Vitor S, Velosa J. Benefits of curing hepatitis C infection. J Gastrointest Liver Dis, 2014;23:85-90.
  • Marinho RT, Donato H, Fernandez-Llimos F, Massano J, Silva JM, Almeida M, Carona Carvalho J, Villanueva T, Eurico Fonseca J. [Think Tank: Strategic Report on the Scientific Biomedical Publication in Portugal]. Acta Med Port 2014;27:1-3.
  • Ribeiro R, Marinho R, Sanches J. An ultrasound based computer-aided diagnosis tool for steatosis detection. IEEE J Biomed Health Inform 2013 Oct 7.
  • Marinho RT, Barreira D. Hepatitis C, Stigma and cure. World Journal of Gastroenterology 2013; 19:6703-6709.
  • Donato H, Marinho RT. [How to Do an Effective Literature Search? The Use of Push and Pull Strategies]. Acta Med Port 2013;26:471-475.
  • Dufour JF, Bargellini I, De Maria N, De Simone P, Goulis I, Marinho RT. Intermediate hepatocellular carcinoma: current treatments and future perspectives. Ann Oncol 2013;24 Suppl 2:ii24-9.